I don't think a keyboard shortcut for every possible action is needed, but I do think being able to work entirely without the mouse is important. Since you already have Ctrl+Shift+F to show the document list, maybe within that pane, support arrow keys to move between documents, n to create a new document, Esc to return to the list, etc. (and something similar for bookmarks and tags).
Be creative. Do it the Dynalist way. Shortcuts for the most common commands, and maybe an omnibar (kind of like the Ctrl+O document list), with a list of all commands that can be filtered by typing in to quickly perform any command.